Welcome to the TF Binding and Perturbation Explorer

This application provides an interactive interface for exploring datasets of transcription factor (TF) binding and gene expression responses following TF perturbation in yeast.

How to Use This App

Navigate through the tabs above to interact with different visualizations:

• Binding: View TF binding profiles across multiple datasets using UpSet plots and correlation matrices.
• Perturbation Response: Explore how TF knockouts or overexpression affect gene expression.
• All Regulator Comparisons: See a global overview of rank response and DTO distributions across all regulators.
• Individual Regulator Comparisons: Zoom in on specific regulators to examine replicate-level perturbation effects.

Getting Started

Begin by selecting a tab to load a dataset and explore visual summaries of binding and expression response relationships.